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Symbol
Name
ID

Snap25
synaptosomal-associated protein 25
MGI:98331

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Aganglionic megacolon

Difficulty walking

Fatigable weakness

Alzheimer disease

Ataxia

Echolalia

Dysarthria

Poor speech

Intellectual disability

Areflexia

Gait disturbance

Developmental regression

Global developmental delay

Delayed ability to walk

Specific learning disability

Seizure

Impaired pain sensation

Disease(s) Associated with SNAP25

congenital myasthenic syndrome 18

Down syndrome

Mouse Phenotypes

seizures

convulsive seizures

myoclonus

abnormal brain morphology

abnormal hippocampus CA3 region morphology

abnormal cerebral cortex morphology

abnormal CNS synaptic transmission

abnormal miniature excitatory postsynaptic currents

decreased prepulse inhibition

abnormal PNS synaptic transmission

abnormal endplate potential

decreased synaptic glutamate release

decreased paired-pulse facilitation

enhanced paired-pulse facilitation

Availability

Mouse Genotype

Snap25^tm1.1Bark/Snap25^tm1.1Bark

Snap25^tm1Bark/Snap25^tm1Bark

Snap25^tm1Mcw/Snap25^tm1Mcw

Snap25^tm1Mtaka/Snap25^tm1Mtaka

Snap25^tm2Mcw/Snap25^tm2Mcw

Snap25^Bdr/Snap25⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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